SCN5A and atrial fibrillation: When filtering according to MAF thresholds defined by pathogenic AF-associated SCN5A variants, 23 out of 24 NUP155 variants possessed a MAF below that of the rarer S216L SCN5A variant (MAF = 6.5 × 10−4), while the remaining V402M NUP155 variant possessed a MAF of 7.0 × 10−4 below that of the less rare, but still pathogenic F2004L SCN5A variant (MAF = 1.9 × 10−3) (Table 1).