For example, the previously reported atrial fibrillation-associated rare NUP155 variants R391H and L503F had respective allele frequencies of 3.977 × 10−6 and 1.193 × 10−5 in gnomAD, setting a precedence for the presence of rare cardiopathogenic NUP155 variants in this cohort. The gene discussed is NUP155; the disease is atrial fibrillation.