In fact, miRISC protein GW182 was first identified from the serum auto-antibodies of patients with neuropathic symptoms (Eystathioy et al., 2002, 2003), and changes in its levels are implicated in Alzheimer's disease (Rouillard et al., 2016; Badhwar et al., 2017). This evidence concerns the gene TNRC6A and early-onset autosomal dominant Alzheimer disease.