Comparing prostate cancer to normal prostate tissue, Suhovskih et al. found increased expression of aggrecan and CSPG4 but reduced decorin levels (Suhovskih et al., 2013), while gastric cancers showed a doubling of overall GAG content and an increase in versican and decorin expression (Theocharis et al., 2003). Here, VCAN is linked to Familial prostate cancer.