While radiotherapy increases LOX secretion in several tumor cell types and in in vivo lung adenocarcinoma xenograft models (Shen et al., 2014), knockdown of LOX2 in DU145 prostate cancer cells using a siRNA approach enhanced their radiosensitivity not only in vitro but also in a xenograft model (Xie et al., 2019). The gene discussed is LOX; the disease is neoplasm.