In vitro studies have demonstrated that increased MMP activity and ECM proteolysis leads to enhanced migration, angiogenesis, and metastasis after radiotherapy, and breast cancer cells showed increased invasion capacity with increased expression of MMP2-activating molecules MT1-MMP and TIMP-2 (Paquette et al., 2007; Artacho-Cordon et al., 2012). The gene discussed is MMP14; the disease is breast carcinoma.