GFER and neoplasm: The first mutant component of the Hpo pathway, wts, was retrieved from a forward genetic screen seeking tumor suppressors, with hpo, sav and mats being later identified based on the same phenotype of tissue overgrowth in mosaic mutant clones (Justice et al., 1995; Xu et al., 1995; Kango-Singh et al., 2002; Tapon et al., 2002; Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003; Lai et al., 2005; Zheng and Pan, 2019).