For instance, miR-495 alone, a miRNA panel of miR-21-3p, miR-21-5p, and miR-99a-5p, a miRNA panel of miR-1246, miR-1307-3p, miR-4634, miR-6861-5p, and miR-6875-5p, PIK3CA proteins, ALU115 combined with ALU247/115 cfDNA, CEA, and CA15-3, methylated APC and RARβ2, as well as Del-1 exosomes, appear to have the highest sensitivities, even as compared to the current imaging screening standards, making them potential screening tool for early breast cancer. The gene discussed is PIK3CA; the disease is breast carcinoma.