For instance, miR-495 alone, a miRNA panel of miR-21-3p, miR-21-5p, and miR-99a-5p, a miRNA panel of miR-1246, miR-1307-3p, miR-4634, miR-6861-5p, and miR-6875-5p, PIK3CA proteins, ALU115 combined with ALU247/115 cfDNA, CEA, and CA15-3, methylated APC and RARβ2, as well as Del-1 exosomes, appear to have the highest sensitivities, even as compared to the current imaging screening standards, making them potential screening tool for early breast cancer. This evidence concerns the gene PIK3CA and breast cancer.