In RA patients with relapse, effector/activated T cell (CD4+CD25+ and CD4+CD25+CD127+) subpopulation numbers were slightly increased at the relapse visit compared with those at baseline (from 10.02 ± 4.51 to 13.17 ± 7.18% and from 4.23 ± 7.73 to 8.65 ± 7.80%, respectively), but these numbers remained unchanged in patients with sustained remission. The gene discussed is CD4; the disease is rheumatoid arthritis.