Notably, hyperglycemia also increases core fucosylation of the TGF receptors-type I and II (TGFβRI and TGFβRII), which enhances its activation of downstream signals, resulting in hypersensitivity to TGFβ ligands (Sun et al., 2017; Wang et al., 2017). Here, TGFB1 is linked to Hyperglycemia.