In addition, Hu et al. (2017) suggested that hydrogen peroxide-inducible clone-5 (Hic-5) may be crucial for c-Met signaling pathways and HCC metastasis because it mediates HGF-induced reactive oxygen species (ROS)-JNK-signaling pathways in HCC (Wu et al., 2015) and may be also a specific and safe target for treating HCC patients. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.