KDR and hepatocellular carcinoma: Among them, sorafenib [against c- rapidly accelerated fibrosarcoma (c-RAF), b-RAF, vascular endothelial growth factor receptor (VEGFR), c-KIT, and platelet-derived growth factor receptor] (Wilhelm et al., 2006; Giordano and Columbano, 2014) was the first drug for first-line treatment of advanced HCC (Marisi et al., 2019; Musso and Beraza, 2019), until the appearance of lenvatinib [against VEGFR/rearranged during transfection proto-oncogene (RET)/fibroblast growth factor receptor (FGFR)] (Kudo et al., 2018).