Protein kinases C ε (PKCε) and golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) regulate HGF-induced c-Met endocytosis (Kermorgant et al., 2004) to direct fluctuating JNK and paxillin signaling pathways which involve HCC cell migration (Hu et al., 2015). The gene discussed is PXN; the disease is hepatocellular carcinoma.