Protein kinases C ε (PKCε) and golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) regulate HGF-induced c-Met endocytosis (Kermorgant et al., 2004) to direct fluctuating JNK and paxillin signaling pathways which involve HCC cell migration (Hu et al., 2015). This evidence concerns the gene MAPK8 and hepatocellular carcinoma.