MAPK3 and hepatocellular carcinoma: Gui et al. (2015, 2017) have demonstrated that SOCS1 overexpression can inhibit HCC cells proliferation and migration by attenuating HGF-induced phosphorylation of c-Met, Gab1, and ERK1/2. MiR-181a can inhibit hepatocarcinogenesis through repressing activation of c-Met (Korhan et al., 2014).