HGF/c-Met signaling pathways are involved in HCC cell invasion via HGF-induced c-Met phosphorylation, AKT phosphorylation, nuclear factor-κB (NF-κB) activation, and matrix metalloproteinase-9 (MMP-9) expression (Wang et al., 2007). This evidence concerns the gene AKT1 and hepatocellular carcinoma.