Uong and Zon (2010) also mentioned that the pathways involved in melanocyte development and proliferation start to be subverted in melanoma formation. BRAF and NRAS (a gene of the RAS family identified for the first time at human neuroblastoma) (Pugh et al., 2013) overactive mutations are found in 65 and 20% of melanomas, respectively. CDKN2A is lacking by melanoma cells, consequently the encoding suppressor genes (INK4a and ARF) are not active (Bandarchi et al., 2010). The gene discussed is CDKN2A; the disease is neuroblastoma.