Besides testing the classical growth factor-mediated therapy approaches in rodent models, AT1R blockers, which are widely used anti-hypertensive medications, were re-discovered to show pro-angiogenic effects after stroke and were reported to increase CBF in the ipsilateral hemisphere (Ito et al., 2002; Engelhorn et al., 2004; Alhusban et al., 2013). Here, AGTR1 is linked to stroke disorder.