In a model of subarachnoid hemorrhage (SAH), a form of stroke that originates from a hemorrhage but often exacerbates through secondary ischemia (van Gijn et al., 2007), increased cerebrovascular myogenic tone and hence, increased cerebrovascular resistance and reduced CBF was associated to augmented S1PR2 signaling in vascular smooth muscle cells (Yagi et al., 2015). This evidence concerns the gene S1PR2 and ischemia.