SCRIB and neoplasm: Coming from opposite directions, both groups identified that expressing an activated form of Ras oncogene at 85D (Ras85D – the most commonly used activated form is often referred to as RasV12, but hereafter is referred to as Ras85DV12) cooperated with mutations in cell polarity regulator genes such as scrib to produce overgrown and invasive tumours in eye-antennal imaginal discs (Figure 3; Brumby and Richardson, 2003; Pagliarini and Xu, 2003).