Regardless, it was shown that Kay was solely responsible for JNK-related differentiation defects and Mmp1 upregulation, but both Kay and Ftz-f1 are necessary for tumour invasiveness, and Ets21C overexpression can cooperate with Ras85DV12 to produce invasive (but non-overgrowing) clones (Külshammer et al., 2015). The gene discussed is MAPK8; the disease is neoplasm.