Upregulating JNK signalling in RafGOF/scrib–/– tumours via hepACT expression led to a reduction in the size of eye-antennal imaginal discs, but adult eyes increased in size, and in both cases the GFP-positive cells (where the different transgenes were clonally expressed) were eliminated, suggesting a non-autonomous effect on the growth of the surrounding wildtype tissue (Uhlirova et al., 2005). The gene discussed is MAPK8; the disease is neoplasm.