MAPK8 and neoplasm: Similarly, another study demonstrated that a majority of the phenotypes seen in Ras85DV12/scrib–/– tumours can be traced back to a network of around 10 interconnected TFs that act downstream of JNK, SWH, and Jak-STAT signalling (Atkins et al., 2016), with Jak-STAT signalling being a key contributor to Ras85DV12/scrib–/– tumour overgrowth (Figure 3; Wu et al., 2010; Atkins et al., 2016).