The largest body of work has examined Scrib/Dlg1/L(2)gl, where animals wholly mutant for any of these components produce neoplastic tumours, in which tissues overproliferate and show aberrant differentiation alongside a disorganised morphology – scrib, dlg1, and l(2)gl are therefore referred to as neoplastic tumour suppressor genes (nTSGs) (Bilder, 2004). The gene discussed is SCRIB; the disease is neoplasm.