Interestingly, proper identification of a classic Drosophila tumour suppressor gene, lethal(2)tumorous imaginal discs, as ALG3, alpha-1,3- mannosyltransferase (Alg3), has shed light on how Grnd might be regulated – Alg3 mutants fail to glycosylate (and thus inactivate) Grnd, enabling persistent TNF-JNK signalling activation via Egr secreted by the fat body, which promotes JNK-mediated tissue overgrowth via SWH signalling inhibition and Yki activation (de Vreede et al., 2018). The gene discussed is MAPK8; the disease is neoplasm.