MAPK8 and neoplasm: Similarly, ectopic JNK signalling also contributes to tumourigenesis driven by Ras85DV12 expression and l(2)gl mutation – Ras85DV12/l(2)gl–/– tumours upregulate JNK signalling, which is thought to proceed via Src oncogene at 42A (Src42A), Ubiquitin-conjugating enzyme variant 1A (Uev1A), and the E2 ubiquitin ligase, Bendless (Ben) (Ma et al., 2013a, b).