Perhaps unsurprisingly, non-autonomous effects of JNK signalling can be tumourigenic, such as the phenomenon of interclonal cooperation, where scrib–/– (or l(2)gl–/–) clones adjacent to Ras85DV12-expressing clones (Ras85DV12//scrib–/–) cooperate to induce tumourigenesis of the Ras85DV12 cells – these tumours appear functionally identical to those where scrib is mutated and Ras85DV12 is expressed in the same cells (Ras85DV12/scrib–/–) (Figure 4B; Wu et al., 2010). The gene discussed is SCRIB; the disease is neoplasm.