PYCARD and neoplasm: This function was supported by experiments, in which ectopic ASC expression induced tumor cells to apoptosis (Conway et al., 2000; Ohtsuka et al., 2004, 2006; Parsons and Vertino, 2006; Ramachandran et al., 2010; Hong et al., 2013), whereas knocking down endogenous ASC inhibited tumor cell death (Ohtsuka et al., 2004; Parsons et al., 2009; Hong et al., 2013).