Moreover, germ cells harboring mutations in components of the dynein-dynactin complex, including Dynein heavy chain 64C (Dhc64C), Lissencephaly-1 (Lis-1), and Dynamitin (also known as Dynactin 2 and DCTN2-p50), give rise to 16 nurse cells and no oocyte (McGrail and Hays, 1997; Liu et al., 1999; Januschke et al., 2002). The gene discussed is DCTN2; the disease is lissencephaly spectrum disorders.