CASP3 and malignant colon neoplasm: Our findings are consistent with the previous studies in the literature reporting that curcumin triggers apoptosis in colon cancer cells by activating caspase 3 (Jaiswal et al., 2002; Rashmi et al., 2005; Su et al., 2006; Zhang et al., 2017; Jalili-Nik et al., 2018).