HMGB1 and neoplasm: Indeed, induction of immunogenic cancer cell death by current therapies, such as chemotherapy, radiotherapy, and/or immunotherapy, can substantially increase the release of DAMPs from dying tumor cells, such as heat-shock proteins (HSPs), adenosine-triphosphate (ATP) or the high mobility group protein B1 (HMGB1) (Tang et al., 2012).