We summarized the recent studies modeling CRC using intestinal organoids with introducing driver mutations in APC, SMAD4, KRAS, TP53, and PIK3CA (Table S1) (Cooks et al., 2013; Onuma et al., 2013; Drost et al., 2015; Matano et al., 2015; Chen et al., 2016; Nakayama et al., 2017; O'Rourke et al., 2017; Riemer et al., 2017; van Lidth de Jeude et al., 2017). The gene discussed is SMAD4; the disease is colorectal carcinoma.