Third, TXNDC11 (thioredoxin domain containing 11 protein) is another protein folding chaperone (Wang et al., 2005) linked to breast cancer through 2,522 mutations in the COSMIC database (as of November, 2018; https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TXNDC11). This evidence concerns the gene TXNDC11 and breast carcinoma.