For example, Fehniger et al., showed that IL-15 transgenic mice develop fatal leukemia from NK and/or CD8 T cell infiltration (Fehniger et al., 2001) and in vitro studies from the same group observed that LGL leukemia can be induced from prolonged culture of human NK cells with IL-15, though this was on the order of >6 months exposure (Mishra et al., 2012). Here, IL15 is linked to T-cell large granular lymphocyte leukemia.