TGFB1 and neoplasm: The effects of TGF-β on NK suppression has been extensively described (Batlle and Massagué, 2019) and is one of the most well-established NK inhibitory cytokine/growth factors in the tumor microenvironment (Bellone et al., 1995; Bergmann et al., 1995; Zaiatz-Bittencourt et al., 2018).