Infection of STAT1 KO mice and STAT1 conditional KO mice using an IFN-γ producing strain of C. neoformans resulted in increased fungal burden, increased M2 activation, and reduced anti-cryptococcal activity compared to WT mice (Hardison et al., 2012; Leopold Wager, 2014, 2015; Leopold Wager et al., 2018). The gene discussed is STAT1; the disease is infection.