A more recent study examined murine alveolar macrophage polarization following infection with high- and low-uptake clinical C. neoformans isolates, and showed that the alveolar macrophages from mice infected with the high-uptake strains had increased expression of M2-associated genes (Arg1, Fizz1, Il13, and Ccl17), while those from mice infected with the low-uptake strains had increased expression of M1-associated genes (Nos2, Ifng, Il6, Tnfa, Mcp1, Csf2, Ip10) (Hansakon et al., 2019), suggesting that cryptococcal strains may influence macrophage polarization. Here, IFNG is linked to infection.