MHC-I expression levels on islet cells were similar in animals infected with a high dose and low dose LCMV (Supplementary Figure 1B), indicating that limited CD8+ T cell infiltration and lack of diabetes induction in high dose infection was likely not due to differential islet MHC-I expression (Ohashi et al., 1993; Lang et al., 2005), but may be related to altered T cell function. The gene discussed is CD8A; the disease is diabetes mellitus.