For example, cytokine production by macrophages and DCs is regulated by the CLR Dectin-1 and complement receptor 3 (CR3) during H. capsulatum infection and by Dectin-1 and TLR2 in Coccidioides infection models (Viriyakosol et al., 2005, 2013; del Pilar Jimenez et al., 2008; Lin et al., 2010; Huang et al., 2015). This evidence concerns the gene CLEC7A and coccidioidomycosis.