THBS1 and acute myeloid leukemia: In the GSE40871 database, when primary AML cells were treated with short-term decitabine (DAC, 100 nM, 3 days), RNA-sequencing results showed that THBS1 expression could be up-regulated significantly (Figure 3D); further genome methylation profiling array demonstrated that after cells were treated with DAC for 3 days, the methylation beta value of THBS1 3′-UTR (chr15: 3988049-39888216) was decreased significantly (Figure 3E), and the methylation beta value of S-Shelf and S-Shore was also significantly decreased with DAC treatment (Figure 3F).