These data suggest that ALDOA, ARNT, C3, CALM1, CAMK2A, CCL28, CCR1, CCR2, CCR3, CCR4, CCR5, CCR8, CCR9, CCRL2, CDC42, CSNK1A1, CX3CR1, CXCR6, DRD3, GNAI2, GNB1, GNB2, GNGT1, GRK6, GRM6, GRM7, HEBP1, HGS, 1L12B, 1L23A, NMUR2, PDGFRB, PIK3CA, PPKCD, PTGER3, PTPN11, PXN, RAC1, RALB, SPARC, SSTR4, STAT2, STAT3, TAS2R3, TAS2R31, TAS2R4, VWF, WNT5A, XCR1, and GRM2 were primarily associated with the modulation and function of differentially expressed CXC chemokines in RCC (Figure 7E). This evidence concerns the gene PIK3CA and renal cell carcinoma.