Although it has been reported that PELP1 can phosphorylate some key kinases such as c-Src (9), PI3K (40, 41), and ERK (42, 43), it was not shown that PELP1 can phosphorylate PI3K and ERK in GC in our study, but PELP1 silencing inhibited the mRNA transcription of PI3K and ERK in GC, moreover, through oncomine dataminig, it was revealed that many human cancers highly expressed PI3K and ERK in mRNA level (our unpublished data). The gene discussed is SRC; the disease is cancer.