In addition, we previously unveiled signaling loops involving LRRC4, AP-2, miR-182, and LRRC4 (the LRRC4-AP-2-miR-182-LRRC4 loop) and LRRC4, miR-185, SP1, DNMT1, and LRRC4 (the LRRC4-miR-185/SP1-DNMT1-LRRC4 loop), which play important role in glioma (18). The gene discussed is DNMT1; the disease is central nervous system cancer.