Mechanistically, DDR1 phosphorylation of BCR on tyrosine 177 alleviates a negative regulatory loop on β-catenin signaling to sustain its oncogenic activity, resulting in the induction of genes that are important for tumor cell dissemination and metastasis development, such as MYC, CYCD1, and LGR5 (42, 48). The gene discussed is DDR1; the disease is neoplasm.