Because CDKN2A deletions encompassing the sequence encoding p14ARF, a component of the p53 pathway, have been documented in 90% of human MM cell lines (6) and TP53 is altered in about 15% of primary MMs, and because the PI3K/PTEN/AKT pathway is activated in most human MPMs, Sementino et al. decided to determine if alterations affecting the same pathways would also induce MM in mice (70). Here, AKT1 is linked to Miyoshi myopathy.