CXCR2 and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, in a study of chronic myelogenous leukemia (CML), IL-8 secreted from BMSCs treated with CML exosomes binds to two transmembrane domain receptors, CXCR-1 and CXCR-2, and increased cell adhesion, motility, and survival of CML cells (76).