CXCL8 and acute myeloid leukemia: Furthermore, inhibition of exosome secretion using an inhibitor of the EV budding regulator neutral sphingomyelinase (GW4869) resulted in a reduction of IL-8 secretion from BMSCs in a BMSC-AML co-culture setting, which had no effect on IL-8 secretion levels in BMSCs cultured alone (75).