BCL2 and acute myeloid leukemia: More specifically, a co-culture experiment showed that chemo-resistant AML cells can induce chemoresistance in chemo-sensitive AML cells by triggering anti-apoptotic protein BCL-2 upregulation in chemo-sensitive AML cells, while chemo-sensitive AML cells could not induce BCL-2 upregulation in other chemo-sensitive AML cells (67).