As a consequence, seven potential feature genes were mined, namely NPHP3, TRABD2A, IFT20, TTC39A, CD44, PLS3, and CDDC23. Additionally, multivariate survival model analysis suggested that these seven feature genes could classify the prognosis of HNSCC well at the AS time and gene expression levels. The gene discussed is NPHP3; the disease is head and neck squamous cell carcinoma.