As a consequence, seven potential feature genes were mined, namely NPHP3, TRABD2A, IFT20, TTC39A, CD44, PLS3, and CDDC23. Additionally, multivariate survival model analysis suggested that these seven feature genes could classify the prognosis of HNSCC well at the AS time and gene expression levels. This evidence concerns the gene PLS3 and head and neck squamous cell carcinoma.