Glioma cells secrete numerous cytokines, chemokines, and growth factors that promote the infiltration of a range of immune cells, such as resident microglia, peripheral macrophages, CD4+ T cells, CD8+ T cells, and regulatory T (Treg) cells, into the tumor (11–13), and these non-neoplastic cells play crucial roles in cancer growth, metastasis, and response to treatment. The gene discussed is CD4; the disease is glioma.