Especially, when analyzing the synergistic effect of increasing the risk of CRC with genotypes, according to the concentration of folate in plasma, it was found that the association of CRC risk was increased at low folate concentrations (≤ 3.08 nmol/L) group in HOTAIR rs7958904 GC+CC and rs1899663 GT+TT types (Figure 2). Here, HOTAIR is linked to colorectal carcinoma.