Cav-1 increases in multiple human drug-resistant cancer cells, such as cisplatin-resistant ovarian cancer cells (7), 5-fluorouracil-resistant colorectal cancer cells (8) and multidrug-resistant lung cancer cells (9), indicating that the resistance to the chemotherapy is tightly correlated with the upregulation of Cav-1 expression. The gene discussed is CAV1; the disease is colorectal cancer.