Collectively, our results provide a novel molecular mechanism that the up-regulation of Cav-1 prevents gastric cancer cells from the cisplatin-induced apoptosis, and it may function as a crucial regulator in the cisplatin-resistance of GC cells by activating the WNT/β-catenin signaling pathway and enhancing the Met-HER2 positive feedback. Here, CAV1 is linked to gastric cancer.