The first reported target of SIRT3 was acetyl-CoA synthetase 2 (AceCS2) (46), that promotes metastasis formation of renal cell carcinoma (47), however, in gastric cancer, loss of AceCS2 expression predicts poor prognosis (48), which further emphasizes the significance of TME. The gene discussed is ACSS1; the disease is renal cell carcinoma.