SIRT2 and acute myeloid leukemia: In acute myeloid leukemia (AML) cell models, SIRT2 promoted the Warburg effect by deacetylating and activating glucose-6-phosphate dehydrogenase (G6PD) enzyme, increasing the production of NADPH, and supporting the biosynthesis of macromolecules that are essential for rapid cell proliferation (42).