Moreover, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that gene sets up-regulated in the high PLXNC1 sub-group were enriched with represented signatures involved in tumor development and progression, such as the JAK-STAT signaling pathway, ECM-receptor interaction, and cAMP signaling pathway (Figure 4B). The gene discussed is PLXNC1; the disease is neoplasm.