Silencing PVT1 inhibited the malignant behaviors of glioma via up-regulating miR-190a-5p or miR-488-3p. miR-190a-5p or miR-488-3p suppressed oncogenesis through regulating oncogene JAGGED1, which was mediated by transcriptional factor MEF2C. The gene discussed is PVT1; the disease is glioma.