Studies show that the upregulation of PVT1 favors its binding to EZH2 (Enhancer of Zeste Homolog-2), a subunit of Polycomb Repressive Complex 2 (PRC2) to inhibit miR-200b expression by increasing histone H3 lysine 27 trimethylation (H3K27me2) on the miR-200b promoter in cervical cancer (28). The gene discussed is EZH2; the disease is cervical carcinoma.