RHO and retinal degeneration: Moreover, Zacks et al. reported that in a mouse model of retinal degeneration caused by a gene mutation in P23H rhodopsin, ER stress-related autophagy led to photoreceptor death, while the treatment of P23H mice with selective phosphodiesterase-4 inhibitor (rolipram) to increase proteasome activity could effectively inhibit ER stress-related autophagy and reduce the rate of retinal degeneration (Qiu et al., 2019).