Members of the PEA3 subfamily have been demonstrated in previous studies be associated with a variety of cancers (Cowden Dahl, Zeineldin & Hudson, 2007; Keld et al., 2010; Kim et al., 2015), but a study conducted by Keld et al. (2011) showed that PEA3 upregulation in isolation does not predict prognosis in any stage of GC. This evidence concerns the gene ETV4 and cancer.