CDK2 and malignant colon neoplasm: In fact, the expression level of E2F2 was very low level in colon cancer and E2F2 inhibition could enhance proliferation and cell cycle of colon cancer cells by suppressing the expression of surviving and regulating the expression of C-MYC, CCNA2, MCM4 (Li et al., 2015) as well as CDK2 (Xanthoulis & Tiniakos, 2013).