CRYAB is a member of the small heat shock protein family (Zhang et al., 2019a; Zhang et al., 2019b; Zhang et al., 2019c), and many studies have confirmed that CRYAB plays an important role in a variety of tumours, such as OSCC (Annertz et al., 2014), colorectal cancer (Li et al., 2017), breast cancer (Kim et al., 2011), and hepatocellular carcinoma (Tang et al., 2009). This evidence concerns the gene CRYAB and breast carcinoma.