TP53 and neoplasm: The result of GESA indicated that the 5 hub genes were significantly involved in critical biological functions and signal pathways that were correlated with carcinogenesis and progression of tumor, such as pathway in cancer, P53 signal pathway, MTOR signal pathway, Notch signal pathway, cell cycle, RRNA metabolic process, ribosome biogenesis and calcium ion transport (Figs. 16 and 17).