Finally, we found that FOS, TP53, JUN, VEGFA, HIF1A, RB1, PTGS2, IL8, OAS2, NFKBIA, and OAS1 are not only the ‘network-hub’ genes that interact with many of the DEGs of MS patients but also the central genes involved in the regulatory network with MS-related miRNAs. Here, PTGS2 is linked to myeloid sarcoma.