As in the skin, various groups have administrated IL-10 to kidney disease models via viral gene transfer and in hydrogels.94–97 As in colitis, some of the challenges of efficient IL-10 administration have been avoided by using ex vivo modified immune cells, and in so doing also serve as a possible insight into IL-10's complex and interconnected role in the pathophysiology of kidney fibrosis. This evidence concerns the gene IL10 and colitis.