IL10 and type 1 diabetes mellitus: Indeed, novel therapies for renal fibrosis are not limited to direct application of IL-10 itself: Romero et al. reported that l-citrulline, an alpha-amino acid, significantly increased IL-10 levels and resulted in remarkably reduced tubulointerstitial fibrosis in a type I diabetic mouse model.98 Some cell-based therapies have also had remarkable results.