For example, IL-10 is clearly an immune-activating cytokine in the treatment of some solid tumors, where it appears to have a stimulating effect on immature T cells by promoting their differentiation into tumor-killing effector T cells.14 In addition, long-term IL-10 exposure or IL-10 application to chronic disease processes may actually exacerbate tissue injury and promote fibrotic outcomes, despite being largely beneficial in the setting of acute inflammation and the early stages of wound healing. The gene discussed is IL10; the disease is neoplasm.