Demonstrating that these T cells homed to the site of intestinal inflammation and had a therapeutic effect in vivo, IL-10 was detected in the colon and its lymph node drainage basins in the weeks after transduction, and similarly, colonic and nodal TNF-α production was decreased in the colon of the transduced mice.87 In contrast to these striking findings, the same transduced T lymphocytes had no effect on acute trinitrobenzene sulfonic acid (TNBS)-induced murine colitis. The gene discussed is TNF; the disease is colitis.