IL10 and Ureteral obstruction: In addition, IL-10 also appears to have an effect on profibrotic signaling pathways that are unique to the kidney, specifically that mesenchymal stromal cell-released IL-10 inhibited RAAS signaling and thereby reduced tubular scarring after unilateral ureteral obstruction (UUO).93 As in the heart, the molecular mechanism behind this effect appeared to be a decrease in inflammatory cytokine mRNA due to HuR transcription inhibition.