In a rat model of monocrotaline-induced PAH, Ito et al. administered IL-10 via intravenous adenoviral vector, which resulted in significantly improved survival rates and a reduction in mean pulmonary artery pressures.64 In addition, we and our collaborators have described a beneficial role of IL-10 delivery in treating pulmonary hypertension. This evidence concerns the gene IL10 and pulmonary hypertension.