Considering the uncertain pathogenesis of MS, there are various treatment plans suggested for patients with MS, among them is vitamin D. 1,25-dihydroxyvitamin D3 (1,25-VD) has general neuroprotective and anti-inflammatory effects.25 Anti-oxidative effects of vitamin D3 may be attributed to the increased expression of G6PD. Here, G6PD is linked to myeloid sarcoma.