IL6 and Insulin resistance: However, glucolipotoxicity is associated with insulin resistance which subsequently causes high body mass index (BMI), high waist circumference, hyperlipidaemia, oxidative stress, and release of inflammatory cytokines such as high sensitive C-reactive protein, hs-CRP, interleukin 6, IL-6, and tumour necrotic factor alpha (TNF-α) [3–6].