FBXO11 and B-cell non-Hodgkin lymphoma: FBXO11 is known to play a critical role in maintenance of B cell levels via the BCL6 pathway and FBXO11 loss of function is frequently observed in B cell lymphoma cell lines and increased B-cell levels (Duan et al., 2012), as we observed in the Fbxo11tmb2/+ knockout mouse.