Jeff (Hardisty et al., 2003), Junbo (Parkinson et al., 2006), and edison (Crompton et al., 2017) mutants are COME mouse models each with single point mutation in the Fbxo11, Evi1, and nischarin genes respectively, identified at MRC Harwell through a deafness screen as a part of a larger scale N-ethyl-N-nitrosourea (ENU) mouse mutagenesis program (Nolan et al., 2000). Here, FBXO11 is linked to deafness.