IGFBP1 and cancer: Specifically, CTD-2218G20.2 was predicted to interact with 86 proteins (Pearson correlation coefficient, PCC > 0.3), some of which, including PSG4, PSG5, and PSG7, could also interact with cancer-related proteins, including KISS1, TIMP2, MMP11, IGFBP1, EGFR, and CDKN1C (Figure 4A).