EDA and hypohidrosis: Zeng et al. (2015) and Gaczkowska et al. (2016) found that HED patients with truncating EDA mutations tend to lose more permanent teeth than patients with non-truncating mutations, while missense mutation patients likely lose fewer permanent teeth than patients with other types of mutations. Our study revealed that patients with EDA missense mutations had a higher frequency of hypohidrosis (P = 0.021).