In the past decade, a number of genetic loci, such as those at 10q26.3, 19q13.43, 17q12, 10q22.3, and 2q31.1, and genes including A2ML1, BPIFA1, CAPN14, GALNT14, FBXO11, FNDC1, FUT2, and TGIF1, have been reported to be associated with OM (Daly et al., 2004; Casselbrant et al., 2009; Chen et al., 2011; Rye et al., 2011b; Rye et al., 2012; Allen et al., 2013; Rye et al., 2014; Santos-Cortez et al., 2015; Einarsdottir et al., 2016; Santos-Cortez et al., 2016; van Ingen et al., 2016; Bhutta et al., 2017a; Santos-Cortez et al., 2018). This evidence concerns the gene BPIFA1 and ocular melanoma.