TGFB1 and ocular melanoma: Fbxo11 is also involved in TGFβ signaling by regulating phosphoSmad2 levels in the epithelial cells of palatal shelves, while a recent report showed that Fbxo11Jf/+ mutations cause failed mesenchymal regression during bulla cavitation, which may be the underlying cause of OM (Tateossian et al., 2009; Del-Pozo et al., 2019a).