TBX1 and ocular melanoma: T-box transcription factor 1 (Tbx1) deficiency disrupts the function of the muscles that control ET function (Fuchs et al., 2015; Funato and Yanagisawa, 2018), while OM model mice carrying mutations in the cell adhesion protein Cdh11 display ME cavitation defects (Kiyama et al., 2018).