Similarly, in children, genetic polymorphisms in TLR2, TLR4, and the TLR co-receptor CD14 have been found to be associated with an increased incidence of OM, while TLR4 also plays a role in acquired adaptive mucosal immunity in the ME (Wiertsema et al., 2006; Emonts et al., 2007; Hafren et al., 2015; Toivonen et al., 2017). This evidence concerns the gene TLR4 and ocular melanoma.