The gene is regulated by vascular genes like VEGF, ACKR1, VEGFA, SIRT1, and TNF. Previous GWASs found variants in TBC1D8 associated with bone mass (Kiel et al., 2007), cognitive decline (Li et al., 2015) and osteoporosis (Hsu et al., 2010) and found that TBC1D8 expression was subject to change under environmental stress. This evidence concerns the gene TNF and osteoporosis.