For instance, in a mouse model of atopic dermatitis (AD) (induced by topical application of 2,4-dinitrofluorobenzene, DNFB), application of hydrocortisone-loaded chitosan nanoparticles transcutaneously have been demonstrated to have superior properties in suppressing pathological manifestations of AD including inflammatory cytokines, IgE and histamine levels, fibroblast infiltration, and anatomical changes at the skin level (95). The gene discussed is IGHE; the disease is Alzheimer disease.