To this end, considerable efforts have been made toward improvement of the tests; CBA for MuSK, LRP4 and clustered AChRs, RIPA for titin and two-step RIPA for AChR and MuSK have contributed significantly toward the reduction of the percentage of SNMG patients and are thus increasingly used in routine diagnosis for the detection of MG autoantibodies (33, 42, 154, 155). This evidence concerns the gene TTN and myasthenia gravis.